The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles.
نویسندگان
چکیده
A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only by-product. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles.
منابع مشابه
Brönsted acidic ionic liquid as a recyclable catalyst for the one pot four-component synthesis of substituted pyrano[2,3-c]pyrazoles
An efficient, mild and environmentally friendly method was reported for the synthesis of An efficient, mild and environmentally friendly method was reported for the synthesis of pyranopyroles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of catalytic amounts of Methyl imidazolium hydrogen sulfate ([Hmim][HSO4]) as an efficient catalyst. These synth...
متن کاملPr3+ doped CoFe2O4: A highly efficient, magnetically recoverable and reusable catalyst for one-pot four-component synthesis of multisubstituted pyrroles
A facile and highly efficient one-pot synthesis of multisubstituted pyrrole derivatives is reported via a four-component reaction of amines, aldehydes, acetylacetone and nitromethane using Pr3+ doped CoFe2O4 as a catalyst in solvent free conditions at 90°C. The catalyst is easily recoverable using magnet and could be reused without a significant loss of catalyti...
متن کاملBrönsted acidic ionic liquid as a recyclable catalyst for the one pot four-component synthesis of substituted pyrano[2,3-c]pyrazoles
An efficient, mild and environmentally friendly method was reported for the synthesis of An efficient, mild and environmentally friendly method was reported for the synthesis of pyranopyroles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of catalytic amounts of Methyl imidazolium hydrogen sulfate ([Hmim][HSO4]) as an efficient catalyst. These synth...
متن کاملThree-component Process for the Synthesis of Some Substituted Pyrroles using Water as a Green Solvent
A novel, convenient and efficient three-component reaction for synthesizing substituted pyrroles from primary amines and electron deficient acetylenic compounds in the presence of ammonium thiocyanate in water leads to the formation of pyrroles in good yields.
متن کاملOne-pot pseudo-five-component synthesis of dihydropyrano[2,3-g] chromenes using sodium phthalimide/[BMIM]BF4 as high efficient catalytic system
An efficient route for the synthesis of dihydropyrano[2,3-g] chromenes via one-pot pseudo-five component cyclization reaction of an aldehyde, malononitrile and 2,5-dihydroxy-1,4-benzoquinone in the presence of an effective and mild catalytic system containing sodium phthalimide and 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BF4) ionic liquid (SPI/IL) was studied. The reacti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 18 شماره
صفحات -
تاریخ انتشار 2013